I'm a Ph.D. not an M.D. (and especially not an endocrinologist), so what follows is not intended to be medical advice for you.
I started out on oral estrogens in the 1970s, and presently received formal endocrinologist's advice to add medroxyprogesterone, first orally and (when the dosage form came on the market) as a renewable time-release implant. Before heading to China the first time, I switched to transdermal estradiol and oral micronised progesterone. Every specialist I dealt with in that period of time advised that the source of danger was estrogen unprotected by co-administered progesterone. That's my take, too, on reading the literature (but see that disclaimer at the start!)
Still on dual regimen. After my stroke, my stroke doc (a refreshingly-blunt dyke)strongly advised continuance of hormones as before, further counselling that the risk of osteoporosis is much greater than the risk of errant clots.
Being of pensionable age, I see and hear enough about age-related osteoporosis, so am motivated to stick with what are now perigeriatric meds. Who'da thunk it? ^_^
I was not aware that progesterone was (on your side of Checkpoint Charlie, at least), considered to be not a maintenance med. My endocrinologist and stronke doc both think it is, at least in my situation.
Bottom line is that none of us have cookie-cutter biology, and so approaches and results will vary. (I can hear my transguy buddies chuckling and chortling.)
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chiming
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Date: 2021-12-27 06:06 pm (UTC)From:I started out on oral estrogens in the 1970s, and presently received formal endocrinologist's advice to add medroxyprogesterone, first orally and (when the dosage form came on the market) as a renewable time-release implant. Before heading to China the first time, I switched to transdermal estradiol and oral micronised progesterone. Every specialist I dealt with in that period of time advised that the source of danger was estrogen unprotected by co-administered progesterone. That's my take, too, on reading the literature (but see that disclaimer at the start!)
Still on dual regimen. After my stroke, my stroke doc (a refreshingly-blunt dyke)strongly advised continuance of hormones as before, further counselling that the risk of osteoporosis is much greater than the risk of errant clots.
Being of pensionable age, I see and hear enough about age-related osteoporosis, so am motivated to stick with what are now perigeriatric meds. Who'da thunk it? ^_^
I was not aware that progesterone was (on your side of Checkpoint Charlie, at least), considered to be not a maintenance med. My endocrinologist and stronke doc both think it is, at least in my situation.
Bottom line is that none of us have cookie-cutter biology, and so approaches and results will vary. (I can hear my transguy buddies chuckling and chortling.)